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Patients can innovate too: Putting a wrap on PICC lines
Saoirse Fitzgerald taking a walk wearing her CareAline wrap. The wrap, designed by her mother, helped keep her central line secure. (Mike & Kezia Fitzgerald) Over the last year and a half I’ve...
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Curing neuroblastoma by making it grow up
All things must grow up. But when nerve cells don't, they turn into neuroblastomas. What if we could get them to grow up again?For decades, the central paradigm behind the treatment of most tumors has...
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Double stem cell transplant and other tools are helping children survive...
Emily Coughlin during her neuroblastoma treatment When Emily Coughlin complained of a sore knee in May 2009, doctors initially suspected Lyme disease. After antibiotics failed to relieve the pain,...
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New cancer target, let-7, unifies theories on neuroblastoma’s origins
Striking the nerve tissue, neuroblastoma is the most common cancer in infants and toddlers. Great strides have been made in its treatment, but advanced cases still are often fatal, and children who...
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Taking a sideswipe at high-risk neuroblastoma
Human neuroblastoma cells. Cancer and other diseases are now understood to spring from a complex interplay of biological factors rather than any one isolated origin. New research reveals that an...
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ctDNA: Bringing ‘liquid biopsies’ to pediatric solid tumors
Brian Crompton with Stephanie Meyer (left) and Kellsey Wuerthele (PHOTO: JOHN DEPUTY) Our blood carries tiny amounts of DNA from broken-up cells. If we have cancer, some of that DNA comes from tumor...
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Overriding resistance to epigenetic inhibitors in neuroblastoma: Targeting PI3K
(IMAGE COURTESY NATIONAL CANCER INSTITUTE) Children’s cancers pose unique challenges. They’re not caused by the same kinds of genetic mutations that cause adult cancers, and only a minority of their...
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